The Neber rearrangement is an organic reaction in which an oxime is converted into an alpha-aminoketone in a rearrangement reaction.[1][2]
The oxime is first converted to a ketoxime tosylate by reaction with tosyl chloride. Added base forms a carbanion which displaces the tosylate group in a nucleophilic displacement to a azirine and added water subsequently hydrolyses it to the aminoketone.
The Beckmann rearrangement is a side reaction.